A connectome-based mechanistic model of focal cortical dysplasia
نویسندگان
چکیده
منابع مشابه
Focal cortical dysplasia – review
Focal cortical dysplasia is a malformation of cortical development, which is the most common cause of medically refractory epilepsy in the pediatric population and the second/third most common etiology of medically intractable seizures in adults.Both genetic and acquired factors are involved in the pathogenesis of cortical dysplasia. Numerous classifications of the complex structural abnormalit...
متن کاملFocal Cortical Dysplasia.
Focal cortical dysplasias are common malformations of cerebral cortical development and are highly associated with medically intractable epilepsy. They have been classified into neuropathological subtypes (type Ia, Ib, IIa, IIb, and III) based on the severity of cytoarchitectural disruption--tangential or radial dispersion, or loss of laminar structure--and the presence of unique cells types su...
متن کاملCortical development and focal cortical dysplasia.
A brief survey of cortical development is presented, focusing on neuronal migration and its alterations. Corticogenesis is achieved through ordered temporospatial steps, via the formation of transient structures, and successive waves of cell proliferation and migration (followed by cell differentiation and maturation), and apoptotic cell death. The appearance of the proliferative ventricular zo...
متن کاملNeuroimaging of focal cortical dysplasia: neuropathological correlations.
Focal cortical dysplasia is a well-known cause of intractable epilepsy with early onset of seizures, and is potentially amenable to surgical therapy. It was first described by Taylor in 1971 as a peculiar malformative disorganisation of the neocortex characterised at histology by loss of cortical lamination and accompanied by giant, dysmorphic neurones and, most frequently, by "balloon cells" l...
متن کاملAn unusual presentation of focal cortical dysplasia.
In a case of histologically proved focal cortical dysplasia, there was an absence of cortex-white matter delineation in the right parietooccipital area only on the T2-weighted images. This pattern correlated with the gross and histologic findings obtained on the resected cerebral tissue.
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ژورنال
عنوان ژورنال: Brain
سال: 2019
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awz009